Human / BloQ Dolor (item no.: 486)

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BloQ Dolor contains Perluxan™ which is a proprietary, standardized supercritical extract of hops cones (Humulus lupulus L.) with multiple mechanisms of action based on alpha acids. These fractions were found to be potent and specific inhibitors of pro-inflammatory chemicals and derivatives, giving Perluxan the power to reduce pain-causing compounds in a short time with a low dose.

Scientific
Perluxan works in concert with numerous biochemical pathways responsible for inflammation with both enzymatic and non-enzymatic sources. Instead of taking weeks or months to begin working, Perluxan may activate to help relieve minor pain beginning with the first dose.
Perluxan is virtually devoid of the undesirable phytoestrogenic and sleep inducing compounds contained in normal hops extracts and powders.
Extensive in-vitro and in-vivo clinical research has been conducted over the last decade to establish the phytomedical credibility of Perluxan. Ongoing clinical studies aim to elucidate the multi-faceted effects of one of history's most well documented plants.
In a state-of-the-art screening assay with human gastrointestinal cells, drug models were used to determine the effectiveness of anti-inflammatory agents extracted from plants. Perluxan was found to reduce pro-inflammatory bio-markers most efficiently, with a lower dosage, amongst a field of 20 botanicals.
After selection from the screening assay, the activity of Perluxan in humans was tested at the William Harvey Research Institute, Royal London School of Medicine in the U.K., using the gold-standard William Harvey Human Modified Whole Blood Assay (WHMA).
In pilot human oral dosing studies, Perluxan was found efficacious in reducing pain-causing biochemicals. 1,000 mg of Perluxan was evaluated to have a similar effect as two (2) 200 mg ibuprofen tablets, with a good tolerability and safety profile for gastrointestinal side effects.

Anti-Inflammatory
Perluxan positively affects a constellation of pro-inflammatory markers of both enzymatic and non-enzymatic origin:

• prostaglanin E₂
• cyclooxygenase 1+2
• interlukein-1
• iisoprostanes
• iiNOS and nNOS
• TTNF-alpha
• NNF-kappa-B

Antioxidant
The alpha acids in Perluxan are potent antioxidants and are effective at both scavenging free radicals and inhibiting the chemical processes that cause oxidation. Extensive laboratory tests have shown that Perluxan consistently exhibits low IC50 values for both Random Scavenging Activity (RSA) and Lipid Peroxidation Inhibiting Activity (LIA), with a strong effect upon copper induced oxidation in LDL.
Recent research has demonstrated that up to 40% of pain-causing biochemicals (e.g. PGE2) in the body come from a non-enzymatic pathway related to free radicals; it is now considered that a viable anti-inflammatory agent should also have antioxidative activity.

Composition
Perluxan is a stable, free-flowing aromatic powder standardized to contain a minimum 30% alpha acids (humulone, co-humulone, etc).

Delivery
Perluxan is bioavailble and well tolerated in tablet and capsule forms.

Dosage
Daily - 500 mg twice per day; Maintenance - 500 mg once per day; Highest - 1000 mg twice per day.
 
Formulations
Perluxan may be used in combination with glucosamine, chondroitin, MSM and other compounds for joint health and mobility. Perluxan has also been shown to boost the potency of some botanical extracts such as curcumin, possibly by improving the absorption of companion